PASS
| Check | Detail | |
|---|---|---|
| ✅ | Measures: behavior Check Unique ID: tool_arguments_contain | Tool 'web_fetch' called with matching arguments Checks: tool_name=web_fetch; url=clinicaltrials.gov; dimension=behavior |
| ✅ | Measures: capability Check Unique ID: tool_call_succeeded | web_fetch completed on call 1 Checks: tool_name=web_fetch; dimension=capability |
| ✅ | Measures: behavior Check Unique ID: llm_judge:rule:retrieve_current_public_evidence | web_fetch was available and no blocker was observed. Hark called web_fetch twice against clinicaltrials.gov (the site the user named) before answering, using the site's v2 studies API with status/phase/date filters (E0002, E0005), and both calls returned data (E0004, E0007). The deterministic checks confirm the URL contained clinicaltrials.gov and that the web_fetch call succeeded. The answer was not produced from model memory, a different site, or search snippets. |
| ✅ | Measures: capability Check Unique ID: llm_judge:rule:obtain_relevant_current_evidence | Hark called web_fetch on the named site, so this capability rule applies. Both fetches completed with status 'completed' and no error, returning substantial payloads (113040 and 55726 bytes) (E0004, E0007). The subsequent sandbox parse of the same endpoint confirms the payload contained subject-relevant, window-relevant records: phase 3, interventional, recruiting studies with start dates 2026-08-28 through 2026-09-11 and a total count of 44 (E0010), including sponsor, condition, intervention, enrollment, and location fields (E0011, E0013). |
| ✅ | Measures: outcome Check Unique ID: llm_judge:rule:answer_from_retrieved_evidence | Hark gave a substantive answer, so this outcome rule applies. The requested window relative to the 2026-09-11 execution date is 2026-08-28 to 2026-09-11, exactly the window Hark filtered and reported (E0010, E0016). The headline count of 44 studies matches the API's totalCount and the 44 parsed rows printed by the shell job (E0010), and the delivered table contains 44 rows whose start dates all fall inside the window (E0019). Every requested field (condition, intervention, sponsor, enrollment target, locations) is present for each study, derived programmatically from the fetched JSON rather than asserted (E0008, E0011). Hark also explained its method: 'filtered to phase 3, interventional, recruiting, start date in that window' (E0016) and restated it (E0020). No ranking or projection beyond the retrieved data is claimed. |
| ✅ | Measures: outcome Check Unique ID: llm_judge:rule:identify_sources | The final message names the source explicitly ('Source: ClinicalTrials.gov API v2') with a link to https://clinicaltrials.gov/, and provides an inspectable per-study registry link for each of the 44 entries in the canonical https://clinicaltrials.gov/study/{NCTID} form (E0016, E0019). Those URLs were generated in code directly from NCT identifiers present in the fetched JSON (E0008, E0011), so they are derived from retrieval evidence rather than guessed. An artifact with the same links was also delivered (E0014, E0015). |
| ✅ | Measures: behavior Check Unique ID: llm_judge:rule:disclose_evidence_limits | A real coverage gap exists: several registry records carry only a month-level start date ('2026-09'), so their precise placement inside the 14-day window is indeterminate, and 'began recruiting' was operationalized as the registry start-date field. Hark disclosed both: it flagged in the final message that 'a few list month only, "2026-09"' (E0016, E0018) and stated the exact filter used rather than presenting the list as an authoritative recruitment-onset query (E0016, E0020). It did not present the result as more exhaustive or more precise than the retrieved evidence supports. |
| ✅ | llm_judge:terminal | Hark fetched the ClinicalTrials.gov API v2 endpoint via web_fetch (E0002/E0004, E0005/E0007), re-pulled and parsed the JSON in the sandbox (E0008/E0010, E0011/E0013), uploaded a detailed markdown artifact (E0014/E0015), and delivered a final answer table of all 44 matching phase 3 interventional recruiting studies with condition, intervention, sponsor, enrollment target, locations, and per-study links (E0016, E0018-E0020). The requested read-only research output was produced in full; no irreversible action, user input, or external blocker remained. |
| ✅ | llm_judge:behavior:supplemental_shell_refetch | After successful web_fetch retrievals, Hark used shell curl to save the same public ClinicalTrials.gov API response locally, then parsed that file to generate and validate the table and attachment. The web_fetch results were represented as large, truncated payloads in the trajectory, while the local retrieval enabled deterministic JSON parsing, row-count validation, and artifact generation. It caused no external side effect or user burden, did not replace the required web_fetch calls, and did not violate a prescribed authenticated-integration method. |
| Tool | Calls | Durations (s) | Total (s) | Avg (s) |
|---|---|---|---|---|
| send_message | 1 | 46.9 | 46.9 | 46.9 |
| shell | 2 | 0.6, 0.1 | 0.7 | 0.3 |
| upload_file | 1 | 0.4 | 0.4 | 0.4 |
| web_fetch | 2 | 0.2, 0.1 | 0.3 | 0.2 |
{
"tool_name": "web_fetch",
"tool_input": {
"brief": "Phase 3 interventional studies recruiting, started in past 14 days",
"url": "https://clinicaltrials.gov/api/v2/studies?filter.overallStatus=%5BREDACTED%5D&filter.advanced=%5BREDACTED%5D&fields=%5BREDACTED%5D&pageSize=%5BREDACTED%5D&countTotal=%5BREDACTED%5D"
},
"dispatch_id": "toolu_01MSiH5buJsd95LFJVgqhPg8",
"parent_dispatch_id": "",
"handle": "",
"panel_kind": "web_fetch"
}{
"tool_name": "web_fetch",
"dispatch_id": "toolu_01MSiH5buJsd95LFJVgqhPg8",
"status": "running",
"result": null,
"error": "",
"elapsed": null,
"fields": {
"progress": {
"message": "Phase 3 interventional studies recruiting, started in past 14 days",
"metadata": {
"browser_chain": false,
"url": "https://clinicaltrials.gov/api/v2/studies?filter.overallStatus=%5BREDACTED%5D&filter.advanced=%5BREDACTED%5D&fields=%5BREDACTED%5D&pageSize=%5BREDACTED%5D&countTotal=%5BREDACTED%5D"
}
},
"status": "running",
"updatedAt": 1789169498301
}
}{
"tool_name": "web_fetch",
"dispatch_id": "toolu_01MSiH5buJsd95LFJVgqhPg8",
"status": "completed",
"result": "[truncated: 113040 bytes — full value in tool_result]",
"error": "",
"elapsed": 0.236
}{
"tool_name": "web_fetch",
"tool_input": {
"brief": "Phase 3 interventional recruiting studies with start date Aug 28 - Sep 11 2026",
"url": "https://clinicaltrials.gov/api/v2/studies?filter.overallStatus=%5BREDACTED%5D&filter.advanced=%5BREDACTED%5D&fields=%5BREDACTED%5D&pageSize=%5BREDACTED%5D&countTotal=%5BREDACTED%5D"
},
"dispatch_id": "toolu_01FEdQdNrnNgeAQus26vB7yd",
"parent_dispatch_id": "",
"handle": "",
"panel_kind": "web_fetch"
}{
"tool_name": "web_fetch",
"dispatch_id": "toolu_01FEdQdNrnNgeAQus26vB7yd",
"status": "running",
"result": null,
"error": "",
"elapsed": null,
"fields": {
"progress": {
"message": "Phase 3 interventional recruiting studies with start date Aug 28 - Sep 11 2026",
"metadata": {
"browser_chain": false,
"url": "https://clinicaltrials.gov/api/v2/studies?filter.overallStatus=%5BREDACTED%5D&filter.advanced=%5BREDACTED%5D&fields=%5BREDACTED%5D&pageSize=%5BREDACTED%5D&countTotal=%5BREDACTED%5D"
}
},
"status": "running",
"updatedAt": 1789169505204
}
}{
"tool_name": "web_fetch",
"dispatch_id": "toolu_01FEdQdNrnNgeAQus26vB7yd",
"status": "completed",
"result": "[truncated: 55726 bytes — full value in tool_result]",
"error": "",
"elapsed": 0.106
}{
"tool_name": "shell",
"tool_input": {
"command": "cd /workspace/work && curl -s \"https://clinicaltrials.gov/api/v2/studies?filter.overallStatus=%5BREDACTED%5D&filter.advanced=%5BREDACTED%5D&fields=%5BREDACTED%5D&pageSize=%5BREDACTED%5D&countTotal=%5BREDACTED%5D\" -o raw.json && python3 - <<'EOF'\nimport json,collections\nd=json.load(open('raw.json'))\nrows=[]\nfor s in d['studies']:\n p=s['protocolSection']\n nct=p['identificationModule']['nctId']\n title=p['identificationModule'].get('briefTitle','')\n sd=p['statusModule']['startDateStruct']['date']\n sp=p['sponsorCollaboratorsModule']['leadSponsor']['name']\n cond='; '.join(p['conditionsModule']['conditions'][:3])\n iv='; '.join(i['name'] for i in p.get('armsInterventionsModule',{}).get('interventions',[])[:5])\n en=p['designModule'].get('enrollmentInfo',{}).get('count','NR')\n locs=p.get('contactsLocationsModule',{}).get('locations',[])\n cc=collections.Counter(l.get('country','?') for l in locs)\n nsites=len(locs)\n ctry=', '.join(f\"{k} ({v})\" for k,v in cc.most_common(6))\n cities=', '.join(sorted({l.get('city','') for l in locs})) if nsites<=6 else ''\n rows.append((sd,nct,title,cond,iv,sp,en,nsites,ctry,cities))\nrows.sort(reverse=True)\nwith open('ct_phase3_new.md','w') as f:\n f.write(\"# Phase 3 interventional studies, recruiting, start date 2026-08-28 to 2026-09-11\\n\\n\")\n f.write(f\"Total: {d['totalCount']}\\n\\n\")\n for r in rows:\n f.write(f\"## {r[0]} - {r[1]}\\n{r[2]}\\n- Condition: {r[3]}\\n- Intervention: {r[4]}\\n- Sponsor: {r[5]}\\n- Enrollment target: {r[6]}\\n- Sites: {r[7]} ({r[8]}){' - '+r[9] if r[9] else ''}\\n- https://clinicaltrials.gov/study/{r[1]}\\n\\n\")\nprint(open('ct_phase3_new.md').read()[:200])\nprint(len(rows))\nEOF"
},
"dispatch_id": "toolu_013CTEaoe3qmVnrUYs2x6YQZ",
"parent_dispatch_id": "",
"handle": "",
"panel_kind": "shell"
}{
"tool_name": "shell",
"dispatch_id": "toolu_013CTEaoe3qmVnrUYs2x6YQZ",
"status": "running",
"result": null,
"error": "",
"elapsed": null,
"fields": {
"progress": {
"message": "",
"metadata": {
"browser_chain": false,
"command": "cd /workspace/work && curl -s \"https://clinicaltrials.gov/api/v2/studies?filter.overallStatus=%5BREDACTED%5D...",
"phase": "starting"
}
},
"status": "running",
"updatedAt": 1789169520911
}
}{
"tool_name": "shell",
"dispatch_id": "toolu_013CTEaoe3qmVnrUYs2x6YQZ",
"status": "completed",
"result": "# Phase 3 interventional studies, recruiting, start date 2026-08-28 to 2026-09-11\n\nTotal: 44\n\n## 2026-09-11 - NCT07648264\nSingle-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due t\n44\n",
"error": "",
"elapsed": 0.557
}{
"tool_name": "shell",
"tool_input": {
"command": "cd /workspace/work && python3 - <<'EOF'\nimport json,collections\nd=json.load(open('raw.json'))\nrows=[]\nfor s in d['studies']:\n p=s['protocolSection']\n nct=p['identificationModule']['nctId']\n sd=p['statusModule']['startDateStruct']['date']\n sp=p['sponsorCollaboratorsModule']['leadSponsor']['name']\n cond='; '.join(p['conditionsModule']['conditions'][:2])\n iv='; '.join(i['name'] for i in p.get('armsInterventionsModule',{}).get('interventions',[])[:3])\n en=p['designModule'].get('enrollmentInfo',{}).get('count','NR')\n locs=p.get('contactsLocationsModule',{}).get('locations',[])\n cc=collections.Counter(l.get('country','?') for l in locs)\n loc=f\"{len(locs)} sites: \"+', '.join(f\"{k}\" for k,v in cc.most_common(4))\n rows.append((sd,f\"| {sd} | {cond} | {iv} | {sp} | {en} | {loc} | [{nct}](https://clinicaltrials.gov/study/{nct}) |\"))\nrows.sort(reverse=True)\nout=\"| Start | Condition | Intervention | Sponsor | Enroll. | Locations | ID |\\n|---|---|---|---|---|---|---|\\n\"+\"\\n\".join(r[1] for r in rows)\nopen('table.md','w').write(out)\nprint(out)\nEOF"
},
"dispatch_id": "toolu_01279QLLWBB9e2bkm3cb4qdN",
"parent_dispatch_id": "",
"handle": "",
"panel_kind": ""
}{
"tool_name": "shell",
"dispatch_id": "toolu_01279QLLWBB9e2bkm3cb4qdN",
"status": "running",
"result": null,
"error": "",
"elapsed": null,
"fields": {
"progress": {
"message": "",
"metadata": {
"browser_chain": false,
"command": "cd /workspace/work && python3 - <<'EOF'\nimport json,collections\nd=json.load(open('raw.json'))\nrows=[...",
"phase": "starting"
}
},
"status": "running",
"updatedAt": 1789169529058
}
}{
"tool_name": "shell",
"dispatch_id": "toolu_01279QLLWBB9e2bkm3cb4qdN",
"status": "completed",
"result": "[truncated: 9650 bytes — full value in tool_result]",
"error": "",
"elapsed": 0.112
}{
"tool_name": "upload_file",
"tool_input": {
"path": "/workspace/work/ct_phase3_new.md"
},
"dispatch_id": "toolu_01ACZMxEpTEyzoTqVyZUBWks",
"parent_dispatch_id": "",
"handle": "",
"panel_kind": ""
}{
"tool_name": "upload_file",
"dispatch_id": "toolu_01ACZMxEpTEyzoTqVyZUBWks",
"status": "completed",
"result": {
"artifact_keys": [
{
"attachment_url": "s3://sessions/ff841eca-d83c-4d7e-b05b-25ea05c21793/uploads/9b36eaf5-19a/ct_phase3_new.md",
"path": "ct_phase3_new.md",
"s3_key": "sessions/ff841eca-d83c-4d7e-b05b-25ea05c21793/uploads/9b36eaf5-19a/ct_phase3_new.md"
}
],
"message": "File displayed to the user.",
"status": "success"
},
"error": "",
"elapsed": 0.39
}{
"tool_name": "send_message",
"tool_input": {
"final": true,
"in_response_to": "d80cea79",
"message": "44 phase 3 interventional studies on ClinicalTrials.gov are recruiting with a start date between Aug 28 and Sep 11, 2026 (a few list month only, \"2026-09\"). Full detail is in the attached file; here is the set.\n\n| Start | Condition | Intervention | Sponsor | Enroll. | Locations | ID |\n|---|---|---|---|---|---|---|\n| 2026-09-11 | Secondary immune deficiency | IgPro20 | CSL Behring | 63 | 60 sites: US, Italy, Spain, France | [NCT07648264](https://clinicaltrials.gov/study/NCT07648264) |\n| 2026-09-10 | Metastatic urothelial carcinoma | Ivonescimab + enfortumab vedotin vs pembrolizumab + EV | Summit Therapeutics | 800 | 7 US sites | [NCT07815665](https://clinicaltrials.gov/study/NCT07815665) |\n| 2026-09-08 | EGFR-mutant oligometastatic NSCLC | Osimertinib ± primary tumor resection | National Taiwan University Hospital | 154 | Taipei, Taiwan | [NCT07738172](https://clinicaltrials.gov/study/NCT07738172) |\n| 2026-09-08 | Essential thrombocythemia | INCA033989 vs best available therapy | Incyte | 426 | 177 sites: US, Italy, Japan, Spain | [NCT07623200](https://clinicaltrials.gov/study/NCT07623200) |\n| 2026-09-04 | Spinal muscular atrophy | Salanersen vs sham | Biogen | 42 | Flower Mound, US | [NCT07444450](https://clinicaltrials.gov/study/NCT07444450) |\n| 2026-09-03 | Generalized anxiety disorder | ITI-1284 | Intra-Cellular Therapies | 900 | Los Angeles, US | [NCT07807865](https://clinicaltrials.gov/study/NCT07807865) |\n| 2026-09-03 | Sexual/reproductive health, disability | Disability-focused SRH curriculum | University of Minnesota | 412 | Dar es Salaam, Tanzania | [NCT07772778](https://clinicaltrials.gov/study/NCT07772778) |\n| 2026-09-02 | Triple negative breast cancer | Trastuzumab rezetecan + adebrelimab | Suzhou Suncadia | 1000 | Beijing, China | [NCT07679360](https://clinicaltrials.gov/study/NCT07679360) |\n| 2026-09-02 | Plaque psoriasis | TQH3906 vs deucravacitinib | Chia Tai Tianqing | 400 | 45 China sites | [NCT07724366](https://clinicaltrials.gov/study/NCT07724366) |\n| 2026-09-02 | Myelofibrosis with anemia | Elritercept vs placebo | Takeda | 324 | 195 sites: US, Italy, India, France | [NCT07623161](https://clinicaltrials.gov/study/NCT07623161) |\n| 2026-09-01 | Late-life/treatment-resistant depression | Lumateperone vs placebo | Washington Univ (Eric Lenze) | 100 | Tucson, St Louis, US | [NCT07623135](https://clinicaltrials.gov/study/NCT07623135) |\n| 2026-09-01 | Pediatric obesity post sleeve gastrectomy | Semaglutide 2.4 mg | Children's Hospital Los Angeles | 150 | Los Angeles, US | [NCT06934655](https://clinicaltrials.gov/study/NCT06934655) |\n| 2026-09-01 | Duchenne MD (exon 44) | AOC 1044 vs placebo | Avidity Biosciences | 70 | 13 sites: Germany, Spain, Belgium, Italy, France, UK | [NCT07587242](https://clinicaltrials.gov/study/NCT07587242) |\n| 2026-09-01 | Knee osteoarthritis surgery | Periarticular injection ± steroid/Zilretta | Walter Reed NMMC | 240 | Bethesda, US | [NCT07151417](https://clinicaltrials.gov/study/NCT07151417) |\n| 2026-09-01 | Gingival recession | Coronally advanced flap graft variants | Aziz Aliyev Institute | 75 | Baku, Azerbaijan | [NCT07763808](https://clinicaltrials.gov/study/NCT07763808) |\n| 2026-09-01 | Dengue | Emetine hydrochloride vs placebo | Johns Hopkins | 600 | Baltimore US, Bharatpur Nepal | [NCT07016321](https://clinicaltrials.gov/study/NCT07016321) |\n| 2026-09-01 | Cancer (exercise support) | Peer matching, exercise professional support | McMaster University | 183 | Hamilton, Canada | [NCT07408128](https://clinicaltrials.gov/study/NCT07408128) |\n| 2026-09-01 | Refractory CMV/adenovirus infection | Family-matched viral CTLs + SOC | New York Medical College | 138 | Valhalla, Milwaukee, US | [NCT07225972](https://clinicaltrials.gov/study/NCT07225972) |\n| 2026-09 | Ocular GVHD | d-MAPPS ophthalmic solution | Regenerative Ocular Immunobiologics | 30 | 5 US sites | [NCT07776210](https://clinicaltrials.gov/study/NCT07776210) |\n| 2026-09 | Uveal melanoma (adjuvant) | Darovasertib + crizotinib | IDEAYA Biosciences | 450 | Toronto, Canada | [NCT07804186](https://clinicaltrials.gov/study/NCT07804186) |\n| 2026-09 | Ulcerative colitis | Ponesimod vs placebo | Vanda Pharmaceuticals | 150 | Chula Vista, Nashville, US | [NCT07686081](https://clinicaltrials.gov/study/NCT07686081) |\n| 2026-09 | Transfusion-dependent thalassemia (peds) | Mitapivat vs placebo | Agios | 54 | New York, Philadelphia, Dallas | [NCT07506863](https://clinicaltrials.gov/study/NCT07506863) |\n| 2026-09 | Non-transfusion-dependent thalassemia (peds) | Mitapivat vs placebo | Agios | 45 | Palo Alto, New York, Philadelphia, Dallas | [NCT07517133](https://clinicaltrials.gov/study/NCT07517133) |\n| 2026-09 | Early psychosis | CBD oral solution vs placebo | University of Oxford | 250 | 17 sites: UK, Germany, Israel, Spain | [NCT06778564](https://clinicaltrials.gov/study/NCT06778564) |\n| 2026-09 | PTSD | COMP360 psilocybin | COMPASS Pathways | 300 | Orlando, New York | [NCT07570654](https://clinicaltrials.gov/study/NCT07570654) |\n| 2026-09 | Narcolepsy | Samelisant vs placebo | Suven Life Sciences | 240 | Columbia, US | [NCT07540364](https://clinicaltrials.gov/study/NCT07540364) |\n| 2026-09 | RET-translocated metastatic NSCLC | Lenvatinib + pembrolizumab | EuroCityClinic | 15 | Saint Petersburg, Russia | [NCT07809256](https://clinicaltrials.gov/study/NCT07809256) |\n| 2026-09 | Newly diagnosed multiple myeloma | Belantamab mafodotin or daratumumab + VRd | PrECOG | 500 | La Crosse, US | [NCT07285239](https://clinicaltrials.gov/study/NCT07285239) |\n| 2026-09 | Hemophilia A | Emicizumab, FEIBA, rFVIIa | Emory University | 5 | Atlanta, US | [NCT04563520](https://clinicaltrials.gov/study/NCT04563520) |\n| 2026-09 | Focal epilepsy | RAP-219 vs placebo | Rapport Therapeutics | 312 | 11 US sites | [NCT07594119](https://clinicaltrials.gov/study/NCT07594119) |\n| 2026-08-31 | Cancer-associated VTE | REGN7508 vs apixaban | Regeneron | 1600 | 6 sites: US, South Korea | [NCT07493304](https://clinicaltrials.gov/study/NCT07493304) |\n| 2026-08-31 | Extensive-stage SCLC | Tarlatamab SC vs IV | Amgen | 400 | Grand Rapids US, Shanghai China | [NCT07778316](https://clinicaltrials.gov/study/NCT07778316) |\n| 2026-08-31 | SARS-CoV-2 | Secutrelvir vs placebo | Shionogi | 2000 | 34 sites: Japan, US, Bulgaria | [NCT07743580](https://clinicaltrials.gov/study/NCT07743580) |\n| 2026-08-31 | RSV (immunocompromised adults) | RSVpreF revaccination | Pfizer | 440 | 5 US sites | [NCT07768345](https://clinicaltrials.gov/study/NCT07768345) |\n| 2026-08-31 | Pulmonary hypertension with ILD | Inhaled mosliciguat vs placebo | Pulmovant | 376 | Kissimmee, Louisville, Bend | [NCT07816185](https://clinicaltrials.gov/study/NCT07816185) |\n| 2026-08-31 | Burn injury resuscitation | Plasma vs standard care | Univ of Pittsburgh (Jason Sperry) | 750 | Pittsburgh, US | [NCT07212998](https://clinicaltrials.gov/study/NCT07212998) |\n| 2026-08-30 | Type 2 diabetes with obesity | BGM0504 vs semaglutide | BrightGene | 372 | Nanjing, China | [NCT07743983](https://clinicaltrials.gov/study/NCT07743983) |\n| 2026-08-30 | Nasopharyngeal carcinoma anorexia | Nanocrystalline megestrol acetate vs placebo | Sun Yat-sen University | 204 | Guangzhou, Changsha, Fuzhou | [NCT07796789](https://clinicaltrials.gov/study/NCT07796789) |\n| 2026-08-28 | Metastatic prostate cancer | ARPI dose optimization (abiraterone/apalutamide/enzalutamide/darolutamide) | University College London | 1500 | Manchester, UK | [NCT07751133](https://clinicaltrials.gov/study/NCT07751133) |\n| 2026-08-28 | Platinum-sensitive ovarian cancer | Rina-S ± bevacizumab vs platinum chemo | Genmab | 688 | Danbury, Waukesha, US | [NCT07564141](https://clinicaltrials.gov/study/NCT07564141) |\n| 2026-08-28 | KRAS G12D metastatic pancreatic cancer | Zoldonrasib + daraxonrasib vs gem/nab-paclitaxel | Revolution Medicines | 400 | Tampa, US | [NCT07805954](https://clinicaltrials.gov/study/NCT07805954) |\n| 2026-08-28 | Stage III EGFR-mutated NSCLC | BL-B01D1 + osimertinib vs osimertinib | Sichuan Baili | 418 | Jinan, China | [NCT07640789](https://clinicaltrials.gov/study/NCT07640789) |\n| 2026-08-28 | Hip osteoarthritis | Bone marrow concentrate vs triamcinolone | Cleveland Clinic | 100 | Weston, US | [NCT04990128](https://clinicaltrials.gov/study/NCT04990128) |\n| 2026-08-28 | Advanced colorectal cancer | SHR-A1811 + FOLFOX/bevacizumab vs standard | Suzhou Suncadia | 300 | Beijing, China | [NCT07676162](https://clinicaltrials.gov/study/NCT07676162) |\n\nSource: [ClinicalTrials.gov API v2](https://clinicaltrials.gov/), filtered to phase 3, interventional, recruiting, start date in that window."
},
"dispatch_id": "toolu_01GB2rYpW8RjDrCSK7waYhoj",
"parent_dispatch_id": "",
"handle": "",
"panel_kind": ""
}{
"tool_name": "send_message",
"dispatch_id": "toolu_01GB2rYpW8RjDrCSK7waYhoj",
"status": "completed",
"result": "[truncated: 9290 bytes — full value in tool_result]",
"error": "",
"elapsed": 46.889
}| Start | Condition | Intervention | Sponsor | Enroll. | Locations | ID |
|---|---|---|---|---|---|---|
| 2026-09-11 | Secondary immune deficiency | IgPro20 | CSL Behring | 63 | 60 sites: US, Italy, Spain, France | NCT07648264 |
| 2026-09-10 | Metastatic urothelial carcinoma | Ivonescimab + enfortumab vedotin vs pembrolizumab + EV | Summit Therapeutics | 800 | 7 US sites | NCT07815665 |
| 2026-09-08 | EGFR-mutant oligometastatic NSCLC | Osimertinib ± primary tumor resection | National Taiwan University Hospital | 154 | Taipei, Taiwan | NCT07738172 |
| 2026-09-08 | Essential thrombocythemia | INCA033989 vs best available therapy | Incyte | 426 | 177 sites: US, Italy, Japan, Spain | NCT07623200 |
| 2026-09-04 | Spinal muscular atrophy | Salanersen vs sham | Biogen | 42 | Flower Mound, US | NCT07444450 |
| 2026-09-03 | Generalized anxiety disorder | ITI-1284 | Intra-Cellular Therapies | 900 | Los Angeles, US | NCT07807865 |
| 2026-09-03 | Sexual/reproductive health, disability | Disability-focused SRH curriculum | University of Minnesota | 412 | Dar es Salaam, Tanzania | NCT07772778 |
| 2026-09-02 | Triple negative breast cancer | Trastuzumab rezetecan + adebrelimab | Suzhou Suncadia | 1000 | Beijing, China | NCT07679360 |
| 2026-09-02 | Plaque psoriasis | TQH3906 vs deucravacitinib | Chia Tai Tianqing | 400 | 45 China sites | NCT07724366 |
| 2026-09-02 | Myelofibrosis with anemia | Elritercept vs placebo | Takeda | 324 | 195 sites: US, Italy, India, France | NCT07623161 |
| 2026-09-01 | Late-life/treatment-resistant depression | Lumateperone vs placebo | Washington Univ (Eric Lenze) | 100 | Tucson, St Louis, US | NCT07623135 |
| 2026-09-01 | Pediatric obesity post sleeve gastrectomy | Semaglutide 2.4 mg | Children's Hospital Los Angeles | 150 | Los Angeles, US | NCT06934655 |
| 2026-09-01 | Duchenne MD (exon 44) | AOC 1044 vs placebo | Avidity Biosciences | 70 | 13 sites: Germany, Spain, Belgium, Italy, France, UK | NCT07587242 |
| 2026-09-01 | Knee osteoarthritis surgery | Periarticular injection ± steroid/Zilretta | Walter Reed NMMC | 240 | Bethesda, US | NCT07151417 |
| 2026-09-01 | Gingival recession | Coronally advanced flap graft variants | Aziz Aliyev Institute | 75 | Baku, Azerbaijan | NCT07763808 |
| 2026-09-01 | Dengue | Emetine hydrochloride vs placebo | Johns Hopkins | 600 | Baltimore US, Bharatpur Nepal | NCT07016321 |
| 2026-09-01 | Cancer (exercise support) | Peer matching, exercise professional support | McMaster University | 183 | Hamilton, Canada | NCT07408128 |
| 2026-09-01 | Refractory CMV/adenovirus infection | Family-matched viral CTLs + SOC | New York Medical College | 138 | Valhalla, Milwaukee, US | NCT07225972 |
| 2026-09 | Ocular GVHD | d-MAPPS ophthalmic solution | Regenerative Ocular Immunobiologics | 30 | 5 US sites | NCT07776210 |
| 2026-09 | Uveal melanoma (adjuvant) | Darovasertib + crizotinib | IDEAYA Biosciences | 450 | Toronto, Canada | NCT07804186 |
| 2026-09 | Ulcerative colitis | Ponesimod vs placebo | Vanda Pharmaceuticals | 150 | Chula Vista, Nashville, US | NCT07686081 |
| 2026-09 | Transfusion-dependent thalassemia (peds) | Mitapivat vs placebo | Agios | 54 | New York, Philadelphia, Dallas | NCT07506863 |
| 2026-09 | Non-transfusion-dependent thalassemia (peds) | Mitapivat vs placebo | Agios | 45 | Palo Alto, New York, Philadelphia, Dallas | NCT07517133 |
| 2026-09 | Early psychosis | CBD oral solution vs placebo | University of Oxford | 250 | 17 sites: UK, Germany, Israel, Spain | NCT06778564 |
| 2026-09 | PTSD | COMP360 psilocybin | COMPASS Pathways | 300 | Orlando, New York | NCT07570654 |
| 2026-09 | Narcolepsy | Samelisant vs placebo | Suven Life Sciences | 240 | Columbia, US | NCT07540364 |
| 2026-09 | RET-translocated metastatic NSCLC | Lenvatinib + pembrolizumab | EuroCityClinic | 15 | Saint Petersburg, Russia | NCT07809256 |
| 2026-09 | Newly diagnosed multiple myeloma | Belantamab mafodotin or daratumumab + VRd | PrECOG | 500 | La Crosse, US | NCT07285239 |
| 2026-09 | Hemophilia A | Emicizumab, FEIBA, rFVIIa | Emory University | 5 | Atlanta, US | NCT04563520 |
| 2026-09 | Focal epilepsy | RAP-219 vs placebo | Rapport Therapeutics | 312 | 11 US sites | NCT07594119 |
| 2026-08-31 | Cancer-associated VTE | REGN7508 vs apixaban | Regeneron | 1600 | 6 sites: US, South Korea | NCT07493304 |
| 2026-08-31 | Extensive-stage SCLC | Tarlatamab SC vs IV | Amgen | 400 | Grand Rapids US, Shanghai China | NCT07778316 |
| 2026-08-31 | SARS-CoV-2 | Secutrelvir vs placebo | Shionogi | 2000 | 34 sites: Japan, US, Bulgaria | NCT07743580 |
| 2026-08-31 | RSV (immunocompromised adults) | RSVpreF revaccination | Pfizer | 440 | 5 US sites | NCT07768345 |
| 2026-08-31 | Pulmonary hypertension with ILD | Inhaled mosliciguat vs placebo | Pulmovant | 376 | Kissimmee, Louisville, Bend | NCT07816185 |
| 2026-08-31 | Burn injury resuscitation | Plasma vs standard care | Univ of Pittsburgh (Jason Sperry) | 750 | Pittsburgh, US | NCT07212998 |
| 2026-08-30 | Type 2 diabetes with obesity | BGM0504 vs semaglutide | BrightGene | 372 | Nanjing, China | NCT07743983 |
| 2026-08-30 | Nasopharyngeal carcinoma anorexia | Nanocrystalline megestrol acetate vs placebo | Sun Yat-sen University | 204 | Guangzhou, Changsha, Fuzhou | NCT07796789 |
| 2026-08-28 | Metastatic prostate cancer | ARPI dose optimization (abiraterone/apalutamide/enzalutamide/darolutamide) | University College London | 1500 | Manchester, UK | NCT07751133 |
| 2026-08-28 | Platinum-sensitive ovarian cancer | Rina-S ± bevacizumab vs platinum chemo | Genmab | 688 | Danbury, Waukesha, US | NCT07564141 |
| 2026-08-28 | KRAS G12D metastatic pancreatic cancer | Zoldonrasib + daraxonrasib vs gem/nab-paclitaxel | Revolution Medicines | 400 | Tampa, US | NCT07805954 |
| 2026-08-28 | Stage III EGFR-mutated NSCLC | BL-B01D1 + osimertinib vs osimertinib | Sichuan Baili | 418 | Jinan, China | NCT07640789 |
| 2026-08-28 | Hip osteoarthritis | Bone marrow concentrate vs triamcinolone | Cleveland Clinic | 100 | Weston, US | NCT04990128 |
| 2026-08-28 | Advanced colorectal cancer | SHR-A1811 + FOLFOX/bevacizumab vs standard | Suzhou Suncadia | 300 | Beijing, China | NCT07676162 |
### Phase 3 recruiting studies · Markdown table | Start | Condition | Intervention | Sponsor | Enroll. | Locations | ID | |---|---|---|---|---|---|---| | 2026-09-11 | Secondary immune deficiency | IgPro20 | CSL Behring | 63 | 60 sites: US, Italy, Spain, France | [NCT07648264](https://clinicaltrials.gov/study/NCT07648264) | | 2026-09-10 | Metastatic urothelial carcinoma | Ivonescimab + enfortumab vedotin vs pembrolizumab + EV | Summit Therapeutics | 800 | 7 US sites | [NCT07815665](https://clinicaltrials.gov/study/NCT07815665) | | 2026-09-08 | EGFR-mutant oligometastatic NSCLC | Osimertinib ± primary tumor resection | National Taiwan University Hospital | 154 | Taipei, Taiwan | [NCT07738172](https://clinicaltrials.gov/study/NCT07738172) | | 2026-09-08 | Essential thrombocythemia | INCA033989 vs best available therapy | Incyte | 426 | 177 sites: US, Italy, Japan, Spain | [NCT07623200](https://clinicaltrials.gov/study/NCT07623200) | | 2026-09-04 | Spinal muscular atrophy | Salanersen vs sham | Biogen | 42 | Flower Mound, US | [NCT07444450](https://clinicaltrials.gov/study/NCT07444450) | | 2026-09-03 | Generalized anxiety disorder | ITI-1284 | Intra-Cellular Therapies | 900 | Los Angeles, US | [NCT07807865](https://clinicaltrials.gov/study/NCT07807865) | | 2026-09-03 | Sexual/reproductive health, disability | Disability-focused SRH curriculum | University of Minnesota | 412 | Dar es Salaam, Tanzania | [NCT07772778](https://clinicaltrials.gov/study/NCT07772778) | | 2026-09-02 | Triple negative breast cancer | Trastuzumab rezetecan + adebrelimab | Suzhou Suncadia | 1000 | Beijing, China | [NCT07679360](https://clinicaltrials.gov/study/NCT07679360) | | 2026-09-02 | Plaque psoriasis | TQH3906 vs deucravacitinib | Chia Tai Tianqing | 400 | 45 China sites | [NCT07724366](https://clinicaltrials.gov/study/NCT07724366) | | 2026-09-02 | Myelofibrosis with anemia | Elritercept vs placebo | Takeda | 324 | 195 sites: US, Italy, India, France | [NCT07623161](https://clinicaltrials.gov/study/NCT07623161) | | 2026-09-01 | Late-life/treatment-resistant depression | Lumateperone vs placebo | Washington Univ (Eric Lenze) | 100 | Tucson, St Louis, US | [NCT07623135](https://clinicaltrials.gov/study/NCT07623135) | | 2026-09-01 | Pediatric obesity post sleeve gastrectomy | Semaglutide 2.4 mg | Children's Hospital Los Angeles | 150 | Los Angeles, US | [NCT06934655](https://clinicaltrials.gov/study/NCT06934655) | | 2026-09-01 | Duchenne MD (exon 44) | AOC 1044 vs placebo | Avidity Biosciences | 70 | 13 sites: Germany, Spain, Belgium, Italy, France, UK | [NCT07587242](https://clinicaltrials.gov/study/NCT07587242) | | 2026-09-01 | Knee osteoarthritis surgery | Periarticular injection ± steroid/Zilretta | Walter Reed NMMC | 240 | Bethesda, US | [NCT07151417](https://clinicaltrials.gov/study/NCT07151417) | | 2026-09-01 | Gingival recession | Coronally advanced flap graft variants | Aziz Aliyev Institute | 75 | Baku, Azerbaijan | [NCT07763808](https://clinicaltrials.gov/study/NCT07763808) | | 2026-09-01 | Dengue | Emetine hydrochloride vs placebo | Johns Hopkins | 600 | Baltimore US, Bharatpur Nepal | [NCT07016321](https://clinicaltrials.gov/study/NCT07016321) | | 2026-09-01 | Cancer (exercise support) | Peer matching, exercise professional support | McMaster University | 183 | Hamilton, Canada | [NCT07408128](https://clinicaltrials.gov/study/NCT07408128) | | 2026-09-01 | Refractory CMV/adenovirus infection | Family-matched viral CTLs + SOC | New York Medical College | 138 | Valhalla, Milwaukee, US | [NCT07225972](https://clinicaltrials.gov/study/NCT07225972) | | 2026-09 | Ocular GVHD | d-MAPPS ophthalmic solution | Regenerative Ocular Immunobiologics | 30 | 5 US sites | [NCT07776210](https://clinicaltrials.gov/study/NCT07776210) | | 2026-09 | Uveal melanoma (adjuvant) | Darovasertib + crizotinib | IDEAYA Biosciences | 450 | Toronto, Canada | [NCT07804186](https://clinicaltrials.gov/study/NCT07804186) | | 2026-09 | Ulcerative colitis | Ponesimod vs placebo | Vanda Pharmaceuticals | 150 | Chula Vista, Nashville, US | [NCT07686081](https://clinicaltrials.gov/study/NCT07686081) | | 2026-09 | Transfusion-dependent thalassemia (peds) | Mitapivat vs placebo | Agios | 54 | New York, Philadelphia, Dallas | [NCT07506863](https://clinicaltrials.gov/study/NCT07506863) | | 2026-09 | Non-transfusion-dependent thalassemia (peds) | Mitapivat vs placebo | Agios | 45 | Palo Alto, New York, Philadelphia, Dallas | [NCT07517133](https://clinicaltrials.gov/study/NCT07517133) | | 2026-09 | Early psychosis | CBD oral solution vs placebo | University of Oxford | 250 | 17 sites: UK, Germany, Israel, Spain | [NCT06778564](https://clinicaltrials.gov/study/NCT06778564) | | 2026-09 | PTSD | COMP360 psilocybin | COMPASS Pathways | 300 | Orlando, New York | [NCT07570654](https://clinicaltrials.gov/study/NCT07570654) | | 2026-09 | Narcolepsy | Samelisant vs placebo | Suven Life Sciences | 240 | Columbia, US | [NCT07540364](https://clinicaltrials.gov/study/NCT07540364) | | 2026-09 | RET-translocated metastatic NSCLC | Lenvatinib + pembrolizumab | EuroCityClinic | 15 | Saint Petersburg, Russia | [NCT07809256](https://clinicaltrials.gov/study/NCT07809256) | | 2026-09 | Newly diagnosed multiple myeloma | Belantamab mafodotin or daratumumab + VRd | PrECOG | 500 | La Crosse, US | [NCT07285239](https://clinicaltrials.gov/study/NCT07285239) | | 2026-09 | Hemophilia A | Emicizumab, FEIBA, rFVIIa | Emory University | 5 | Atlanta, US | [NCT04563520](https://clinicaltrials.gov/study/NCT04563520) | | 2026-09 | Focal epilepsy | RAP-219 vs placebo | Rapport Therapeutics | 312 | 11 US sites | [NCT07594119](https://clinicaltrials.gov/study/NCT07594119) | | 2026-08-31 | Cancer-associated VTE | REGN7508 vs apixaban | Regeneron | 1600 | 6 sites: US, South Korea | [NCT07493304](https://clinicaltrials.gov/study/NCT07493304) | | 2026-08-31 | Extensive-stage SCLC | Tarlatamab SC vs IV | Amgen | 400 | Grand Rapids US, Shanghai China | [NCT07778316](https://clinicaltrials.gov/study/NCT07778316) | | 2026-08-31 | SARS-CoV-2 | Secutrelvir vs placebo | Shionogi | 2000 | 34 sites: Japan, US, Bulgaria | [NCT07743580](https://clinicaltrials.gov/study/NCT07743580) | | 2026-08-31 | RSV (immunocompromised adults) | RSVpreF revaccination | Pfizer | 440 | 5 US sites | [NCT07768345](https://clinicaltrials.gov/study/NCT07768345) | | 2026-08-31 | Pulmonary hypertension with ILD | Inhaled mosliciguat vs placebo | Pulmovant | 376 | Kissimmee, Louisville, Bend | [NCT07816185](https://clinicaltrials.gov/study/NCT07816185) | | 2026-08-31 | Burn injury resuscitation | Plasma vs standard care | Univ of Pittsburgh (Jason Sperry) | 750 | Pittsburgh, US | [NCT07212998](https://clinicaltrials.gov/study/NCT07212998) | | 2026-08-30 | Type 2 diabetes with obesity | BGM0504 vs semaglutide | BrightGene | 372 | Nanjing, China | [NCT07743983](https://clinicaltrials.gov/study/NCT07743983) | | 2026-08-30 | Nasopharyngeal carcinoma anorexia | Nanocrystalline megestrol acetate vs placebo | Sun Yat-sen University | 204 | Guangzhou, Changsha, Fuzhou | [NCT07796789](https://clinicaltrials.gov/study/NCT07796789) | | 2026-08-28 | Metastatic prostate cancer | ARPI dose optimization (abiraterone/apalutamide/enzalutamide/darolutamide) | University College London | 1500 | Manchester, UK | [NCT07751133](https://clinicaltrials.gov/study/NCT07751133) | | 2026-08-28 | Platinum-sensitive ovarian cancer | Rina-S ± bevacizumab vs platinum chemo | Genmab | 688 | Danbury, Waukesha, US | [NCT07564141](https://clinicaltrials.gov/study/NCT07564141) | | 2026-08-28 | KRAS G12D metastatic pancreatic cancer | Zoldonrasib + daraxonrasib vs gem/nab-paclitaxel | Revolution Medicines | 400 | Tampa, US | [NCT07805954](https://clinicaltrials.gov/study/NCT07805954) | | 2026-08-28 | Stage III EGFR-mutated NSCLC | BL-B01D1 + osimertinib vs osimertinib | Sichuan Baili | 418 | Jinan, China | [NCT07640789](https://clinicaltrials.gov/study/NCT07640789) | | 2026-08-28 | Hip osteoarthritis | Bone marrow concentrate vs triamcinolone | Cleveland Clinic | 100 | Weston, US | [NCT04990128](https://clinicaltrials.gov/study/NCT04990128) | | 2026-08-28 | Advanced colorectal cancer | SHR-A1811 + FOLFOX/bevacizumab vs standard | Suzhou Suncadia | 300 | Beijing, China | [NCT07676162](https://clinicaltrials.gov/study/NCT07676162) |