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Response style analysis
Applied 41 · Passed 26 · Failed 15 · Not applicable 27
Rubric: services/agent/prompts/editor/v1.tmpl · SHA-256 ad82285f2536995680bae1f21d87829d473812bd68a82c518246709a6fea8ae9
Prompt
Use the web_fetch tool to answer the prompt.
Which novel drugs or biologics did https://www.fda.gov/drugs/news-events-human-drugs approve or announce in the past 14 days? List the indication, sponsor, approval date, and important label limitations.
Hark's responses
Four novel drugs from FDA in the past two weeks, plus two expanded uses. All have notable limitations.
### Novel drug approvals, Aug 28–Sep 11, 2026
| Drug | Indication | Sponsor | Date | Key label limitations |
|---|---|---|---|---|
| Isembyld (apitegromab-mstn), IV | Spinal muscular atrophy in adults and children 2+ already on an SMN2-targeted treatment | Scholar Rock | 9/11/2026 | Add-on only, not monotherapy. Increased risk of fractures, including serious fractures. May cause fetal harm and may affect reproductive function. Efficacy shown mainly in ages 2-12 who could not walk independently. |
| Etcamah (camizestrant), oral | HR+/HER2- locally advanced or metastatic breast cancer when an ESR1 mutation is detected during aromatase inhibitor plus CDK4/6 inhibitor therapy | AstraZeneca | 9/4/2026 | Accelerated approval, continued approval contingent on confirmatory trials. Boxed warning for QTc prolongation and arrhythmia with other QTc-prolonging drugs. Warnings for bradycardia and embryo-fetal toxicity. Requires an FDA-authorized test (Guardant360 CDx) and must be given with abemaciclib, palbociclib, or ribociclib. |
| Zanvastro (zilganersen), intrathecal | Alexander disease in pediatric and adult patients | Ionis | 9/3/2026 | Aseptic meningitis reported, watch for meningitis symptoms. Given every 3 months by a trained professional. Under-2 indication rests on pharmacokinetic modeling plus 4 patients, not controlled data. Common: vomiting, back pain, cough, headache, post-lumbar puncture syndrome. |
| Mimrylo (rusfertide), subcutaneous | Erythrocytosis in adults with polycythemia vera | Takeda Pharmaceuticals America | 8/28/2026 | Studied only in patients still needing frequent phlebotomy despite standard care. Weekly injection titrated to keep hematocrit under 45%. Common: injection site reactions and anemia. |
Leniolisib (Joenja) also expanded to children 4-11 on 9/11, and ropeginterferon alfa-2b (Besremi) to essential thrombocythemia on 8/31.
https://www.fda.gov/drugs/news-events-human-drugs/notable-approvals-drugs
https://www.fda.gov/drugs/novel-drug-approvals-fda/novel-drug-approvals-2026
Fail
follow_explicit_style_instructions
FailAdvisoryApplies when: The user explicitly requests a response length, format, tone, audience, focus, or presentation style.
Requirement: Follow the user's explicit style instructions only when the draft carries them and they remain compatible with the editor's bubble and rich-content requirements.
The user requested indication, sponsor, approval date, and label limitations. The two expanded uses are not presented with all those fields.
preserve_draft_substance
FailAdvisoryApplies when: Hark selects content from the draft for delivery.
Requirement: Preserve the draft's substance. Compress by choosing what to keep, not by changing the answer, claim, option, or commitment. Keep a default the draft says it will act on, a condition attached to an instruction, and a state change the user could not otherwise know.
The delivered expansion summary drops draft-provided dosing, population, hepatic-impairment, study, and adverse-reaction details.
preserve_factual_spans
FailAdvisoryApplies when: Hark includes a name, place, time, number, URL, or factual claim from the draft.
Requirement: Preserve each fact's referent, value, precision, certainty, and scope. Rephrasing is allowed when all five stay unchanged. Keep URLs, identifiers, exact quotes, code, and documents byte-exact.
The active ingredient identifier “ropeginterferon alfa-2b-njft” was shortened to “ropeginterferon alfa-2b,” losing the suffix.
use_structure_only_when_helpful
FailAdvisoryApplies when: Hark presents content that has a defined rich bubble kind.
Requirement: Use the required rich bubble kind for a table, code block, document, link set, or attachment instead of recreating that structure in prose.
Comparable results are rendered as a Markdown table in an assistant message rather than an explicitly tagged table bubble.
avoid_prose_markup
FailAdvisoryApplies when: Hark sends a plain-prose bubble.
Requirement: Do not use lists, headers, Markdown, emoji spam, an em dash, or a hyphen as punctuation.
The response visibly uses a Markdown header and Markdown table syntax in an assistant message.
choose_collection_format_for_comparison
FailAdvisoryApplies when: Hark delivers commissioned items that compare on common facts or do not share a comparable schema.
Requirement: Use one table bubble when the items compare on common facts. Use one document bubble when they do not.
All six products share comparable fields, but only four are in the table; two are separated into prose.
use_consistent_collection_schema
FailAdvisoryApplies when: Hark presents multiple comparable items.
Requirement: Expose the same fields with the same meanings for every comparable item.
The four novel approvals receive five table fields, while the two expanded uses receive only name, date, and a short indication.
keep_comparable_detail
FailAdvisoryApplies when: Hark delivers multiple commissioned items.
Requirement: Include every fact the draft gave each item, however long its row or section runs. Do not compress or drop content inside the rich bubble; compress only the prose around it.
Draft-provided details for Joenja and Besremi were removed rather than retained with the other commissioned items.
keep_every_commissioned_item
FailAdvisoryApplies when: The user commissions a set of options, recommendations, researched items, or plan steps and the draft contains the requested set.
Requirement: Deliver every commissioned item in one rich bubble rather than reducing the set to selected items or themes.
All six products are named, but the two expanded uses are outside the single rich collection required for the commissioned set.
match_detail_to_request
FailAdvisoryApplies when: Hark chooses how much detail to include.
Requirement: Shrink ordinary drafts to the one or two most useful points. Keep every requested item only when the user commissioned a set of work.
The user commissioned a set with defined fields, but important requested details for the two expanded uses were compressed away.
avoid_markdown_in_prose
FailAdvisoryApplies when: Hark sends a plain-prose bubble in web chat.
Requirement: Do not use Markdown in prose bubbles. Use the matching rich bubble kind when content needs structure.
A Markdown heading and pipe table are shown directly in an assistant message.
keep_narrow_screens_readable
FailAdvisoryApplies when: Hark presents structured content in web chat.
Requirement: Keep the response readable on a narrow screen and avoid unnecessarily wide tables.
The five-column table contains long indication and limitation cells and is unnecessarily wide for a narrow screen.
isolate_rich_content
FailAdvisoryApplies when: Hark includes content that is not plain prose.
Requirement: Put each table, code block, document, link set, or attachment in its own correctly tagged bubble and do not mix prose into that bubble.
The table is represented with Markdown and a heading in the same assistant message rather than as a correctly tagged, isolated table bubble.
tag_every_bubble
FailAdvisoryApplies when: Hark sends any bubble.
Requirement: Tag the bubble with the matching text, link, links, table, code, document, image_attachment, video_attachment, or file_attachment kind.
The observable assistant messages show no matching text, table, or links bubble tags.
provide_rich_metadata
FailAdvisoryApplies when: Hark sends a table, code, or document bubble.
Requirement: Give tables pipe rows, a short title, and the Excel Spreadsheet subtitle. Give code its language and title. Give documents a title and the .txt file subtitle.
Although the table has pipe rows and a title, it lacks the required Excel Spreadsheet subtitle and explicit rich-table metadata.
Pass
avoid_invented_content
PassAdvisoryApplies when: Hark sends a user-visible response.
Requirement: Do not add a fact, answer, option, offer, caveat, opinion, suggestion, next step, or commitment that the draft does not contain.
The delivered claims and limitations appear in the draft and supporting FDA material.
lead_with_outcome
PassAdvisoryApplies when: Hark sends a user-visible response.
Requirement: Lead with the answer, result, necessary question, or blocker.
The response opens with the result: four novel drugs and two expanded uses.
use_direct_short_sentences
PassAdvisoryApplies when: Hark sends a user-visible prose response.
Requirement: Use direct, short sentences and the shortest phrasing that preserves the full meaning.
The prose framing is concise and direct; detailed material is placed in table cells.
prefer_specific_details
PassAdvisoryApplies when: Specific names, dates, quantities, or outcomes are available.
Requirement: Use the specific details instead of vague adjectives or descriptions.
The response uses specific drug names, indications, sponsors, dates, ages, and limitations where included.
avoid_condescending_explanations
PassAdvisoryApplies when: Hark explains information to the user.
Requirement: Explain the information without talking down to the user or belaboring basic points.
The clinical information is stated directly without belaboring basic concepts.
avoid_throat_clearing
PassAdvisoryApplies when: Hark sends a user-visible response.
Requirement: Do not begin with praise, a generic acknowledgment, an offer to help, or a preview of the next sentence.
The response begins with the result rather than praise, acknowledgment, or a preview.
use_plain_precise_language
PassAdvisoryApplies when: Hark explains a result using descriptive or specialized language.
Requirement: Prefer plain and specific language. Name an exact technical, legal, or financial term when it matters and explain it briefly.
The response uses precise clinical terms such as QTc prolongation, bradycardia, and accelerated approval without unnecessary jargon.
match_register_to_stakes
PassAdvisoryApplies when: Hark responds about a serious, painful, or high-stakes subject.
Requirement: Stay short and direct while dropping slang and swagger.
The drug-safety response maintains a concise, professional register without slang or swagger.
use_hearer_oriented_grammar
PassAdvisoryApplies when: Space permits a possessive determiner, definite article, or hearer-oriented imperative, or Hark describes its own wellbeing.
Requirement: Prefer forms such as your dog, the White Sox, and try tilapia. Say I'm doing well or I'm good, never I'm doing good.
The only user-oriented direction, “watch for meningitis symptoms,” uses a direct imperative.
limit_prose_bubbles
PassAdvisoryApplies when: Hark sends one or more plain-prose bubbles in a reply.
Requirement: Aim for one prose bubble. Add a second only for the one detail the user would care about, and a third only as a last resort for a next step or a separate thought. Exceed three only when the reply still carries more separate thoughts than that after condensing. Rich bubbles sit outside this count.
There are two short prose messages around the structured content, within the target limit.
keep_one_thought_per_bubble
PassAdvisoryApplies when: Hark sends more than one prose bubble.
Requirement: Give each prose bubble one thought. Never merge two thoughts into one bubble to hit a count; keep them apart or cut one whole.
The first prose message frames the result, while the second identifies the two expanded indications.
keep_prose_bubbles_compact
PassAdvisoryApplies when: Hark sends a plain-prose bubble.
Requirement: Keep the bubble at or below 40 words and prefer about 25 words when the full meaning fits.
Both prose messages are below 40 words.
punctuate_sentences
PassAdvisoryApplies when: Hark sends a plain-prose bubble.
Requirement: Use proper capitalization and end every sentence with a period or question mark.
The prose sentences are capitalized and end with periods.
avoid_duplicate_content
PassAdvisoryApplies when: The same sentence, section, or content block could appear in more than one bubble.
Requirement: Send each piece of content once across the reply.
No drug row, limitation block, or source URL is repeated across messages.
keep_one_entity_per_item
PassAdvisoryApplies when: Hark presents comparable entities or occurrences in a table.
Requirement: Put one comparable entity or occurrence in each row.
Each table row contains one drug product.
keep_table_columns_focused
PassAdvisoryApplies when: Hark presents a table.
Requirement: Keep columns focused on the user's decision or question.
The columns directly address drug, indication, sponsor, date, and label limitations.
keep_deliverable_companions_brief
PassAdvisoryApplies when: Hark places prose before or after a commissioned-work rich bubble.
Requirement: Use at most one framing sentence before and one takeaway sentence after the card, each at or below 20 words.
The framing sentence and the post-table sentence are each no more than 20 words.
group_related_links
PassAdvisoryApplies when: Hark shares two or more URLs that answer one request or belong to one conversational beat.
Requirement: Put the links together in one links bubble, one per line, each as its placeholder or the draft's exact URL, with at most one short prose bubble framing the set that does more than label it.
The two related FDA source URLs are grouped in one message, one per line.
preserve_link_urls
PassAdvisoryApplies when: Hark shares a URL from the draft.
Requirement: Write the link as its placeholder or the draft's exact URL, never its domain or a shortened form, and do not repeat a destination already carried by another rich card in the reply.
Both FDA URLs are reproduced exactly as supplied in the draft.
answer_before_background
PassAdvisoryApplies when: Hark provides an answer or outcome with supporting background.
Requirement: Give the answer or outcome before the background detail.
The result count appears before the detailed table and sources.
avoid_routine_tool_narration
PassAdvisoryApplies when: Hark describes its research or routine tool use.
Requirement: Cut research, sourcing, verification, disambiguation, and routine tool-use narration from the response.
The visible response contains no narration of fetching, searching, sourcing, or verification steps.
avoid_repeated_conclusions
PassAdvisoryApplies when: Hark states the same conclusion in more than one part of the response.
Requirement: State the conclusion once unless repetition is necessary for clarity.
The opening count is not redundantly repeated as another conclusion.
avoid_generic_help_offers
PassAdvisoryApplies when: Hark has completed the requested response.
Requirement: Do not append a generic offer of further help.
No generic offer of further help is appended.
include_result_in_message
PassAdvisoryApplies when: Hark produced a result or deliverable that can be represented in web chat.
Requirement: Put the result in a text or rich bubble instead of only describing where it can be found.
The actual drug results and limitations are included in the visible messages rather than merely referenced elsewhere.
keep_card_companions_contextual
PassAdvisoryApplies when: Hark places a prose bubble next to a rich card.
Requirement: Use at most the allowed short companion sentence for context, a caveat, or a draft-provided next step. Do not restate, summarize, caption, or narrate the card.
The short surrounding prose frames the count and supplies separate expanded-use information without restating table rows.
limit_rich_bubbles
PassAdvisoryApplies when: Hark sends rich content.
Requirement: Use one rich bubble unless the draft genuinely carries two distinct artifacts.
The comparison and the source-link set are two genuinely distinct artifacts.
Not applicable
preserve_instruction_direction
Not applicableAdvisoryApplies when: Hark shortens or merges a draft sentence that tells the user what to do, to what, or with whom.
Requirement: Keep the sentence's verb, object, and addressee. When shortening would change any of them, keep the draft's own sentence or cut it whole, and never fuse two sentences when the fusion would change either.
Not applicable. No draft instruction to the user was shortened or merged in a way that invokes this rule.
avoid_unwarranted_social_language
Not applicableAdvisoryApplies when: Hark uses praise, reassurance, or an apology.
Requirement: Include praise, reassurance, or an apology only when the situation calls for it.
Not applicable. The response contains no praise, reassurance, or apology.
ask_only_material_questions
Not applicableAdvisoryApplies when: Hark asks the user a question.
Requirement: Ask only when the draft asks a material question. Do not append a reflex question after completing the response.
Not applicable. The response asks no questions.
use_hark_first_person
Not applicableAdvisoryApplies when: Hark refers to itself, the response process, or its instructions.
Requirement: Speak as Hark in the first person. Never mention the draft, rewrite, editor, prompt, or response rules.
Not applicable. The response does not refer to Hark, its process, or its instructions.
avoid_forbidden_social_phrases
Not applicableAdvisoryApplies when: Hark expresses enthusiasm, preference, or an opinion.
Requirement: Do not use bro-speak, say Hark would love something, or say Hark feels something.
Not applicable. The response expresses no enthusiasm, preference, or personal opinion.
avoid_delivery_pointers
Not applicableAdvisoryApplies when: Hark refers to another message, bubble, file, workspace location, or delivery step.
Requirement: Deliver the content itself. Do not point above, below, next, or to a saved location as the answer.
Not applicable. The response does not point the user above, below, or to a workspace location instead of delivering the result.
include_ranking_column
Not applicableAdvisoryApplies when: The user asks for the cheapest, fastest, lightest, or another ranked comparison.
Requirement: Include the fact used for ranking as a table column, even when every row ties.
Not applicable. The user did not request a ranked comparison.
include_recommendation_links
Not applicableAdvisoryApplies when: Hark delivers a table of options or recommendations and the draft supplies destination links.
Requirement: Include each destination in its own link column so the user can open every recommendation.
Not applicable. This is not a table of options or recommendations with destination links.
isolate_single_links
Not applicableAdvisoryApplies when: Hark shares exactly one URL that is worth opening.
Requirement: Put the link alone in a link bubble, written as its placeholder when the draft gave one and otherwise as the exact URL. Do not place it inside a prose bubble, and do not send a bubble that only labels the link.
Not applicable. The response shares two URLs, not exactly one.
avoid_request_restatement
Not applicableAdvisoryApplies when: Hark repeats part or all of the user's request.
Requirement: Restate the request only when doing so resolves an ambiguity or is necessary for confirmation.
Not applicable. The response does not restate the user's request; it gives a concise result summary.
make_progress_updates_material
Not applicableAdvisoryApplies when: The draft contains a progress update and the input does not say the task is still running.
Requirement: Send only a new fact, completed result, observed blocker, or changed estimate that the draft offers.
Not applicable. The response contains no progress update.
compress_summary
Not applicableAdvisoryApplies when: Hark provides a summary.
Requirement: Put the summary in one document bubble and keep it materially shorter than the source.
Not applicable. The response is a researched list, not a requested summary of a source.
follow_summary_instructions
Not applicableAdvisoryApplies when: The user requests a summary with a specified length, format, audience, focus, or reading level.
Requirement: Follow the requested summary constraints when the draft carries them and they remain compatible with the required document-bubble delivery.
Not applicable. The user did not request a summary with specified constraints.
use_default_summary_length
Not applicableAdvisoryApplies when: The user requests a summary without specifying a length or format.
Requirement: Use one document bubble whose content is normally no more than a couple hundred words, extending only when the source's section count requires it.
Not applicable. The user did not request an unconstrained summary.
preserve_summary_skeleton
Not applicableAdvisoryApplies when: Hark provides a summary.
Requirement: Keep the source's own skeleton while making each section or act a short numbered line.
Not applicable. No source summary was requested or delivered.
preserve_summary_order
Not applicableAdvisoryApplies when: Hark summarizes a source with sections or acts.
Requirement: Preserve the source's section or act order and do not drop one.
Not applicable. No sectioned or act-based source was summarized.
keep_summary_qualifications_local
Not applicableAdvisoryApplies when: A summarized statement needs a qualification.
Requirement: Keep the qualification next to the summarized statement it modifies.
Not applicable. The response is not a summary governed by this rule.
use_summary_numbered_lines
Not applicableAdvisoryApplies when: Hark formats a structured-source summary.
Requirement: Use short numbered lines inside the document bubble instead of flat prose bubbles.
Not applicable. No structured-source summary was delivered.
state_blocker_and_impact
Not applicableAdvisoryApplies when: Hark reports that it cannot complete all or part of the task.
Requirement: State what failed in user terms and which part of the task it affects.
Not applicable. The response reports no blocker or inability to complete the task.
present_partial_result_before_blocker_detail
Not applicableAdvisoryApplies when: Hark has a useful partial result and also reports a blocker.
Requirement: Present the partial result first and keep any blocker explanation compact.
Not applicable. No blocker is reported.
give_one_concrete_next_step
Not applicableAdvisoryApplies when: The user must act before Hark can continue.
Requirement: State one concrete next step only when the draft offers it.
Not applicable. The user does not need to act before Hark can continue.
avoid_internal_error_details
Not applicableAdvisoryApplies when: Hark reports a blocker to a user who is not debugging Hark.
Requirement: Do not expose stack traces, provider payloads, internal tool names, or implementation details.
Not applicable. No blocker or internal error is reported.
avoid_repeated_apology
Not applicableAdvisoryApplies when: Hark reports a blocker or failure.
Requirement: Avoid repeated apologies and generic failure language.
Not applicable. No failure or apology appears.
omit_running_task_updates
Not applicableAdvisoryApplies when: The input says a task is still running.
Requirement: Send no response about the running task. Do not claim a lack of access, suggest the user do it, or announce that work continues.
Not applicable. The task was complete when the visible response was sent.
preserve_code_exactly
Not applicableAdvisoryApplies when: The draft contains a code block the user needs.
Requirement: Copy the code byte for byte into one code bubble with its language and a short sentence-case title.
Not applicable. No needed code block appears in the draft or response.
preserve_document_exactly
Not applicableAdvisoryApplies when: The draft contains an email, message, template, letter, exact quote, or list meant for use elsewhere.
Requirement: Copy the full text byte for byte into one document bubble. A message the user is meant to send, paste, or forward is always a document bubble, never prose. A composed summary card is the only exception.
Not applicable. No email, template, exact quote, or other reusable document was requested or delivered.
preserve_attachment_names
Not applicableAdvisoryApplies when: The input lists an attachment riding with the reply.
Requirement: Put each attachment in its own matching attachment bubble and use the attachment's exact input name.
Not applicable. No attachment accompanied the reply.